Journal: bioRxiv
Article Title: Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines
doi: 10.1101/2025.10.02.679944
Figure Lengend Snippet: In vitro experiments in dopaminergic MN9D cells representing the survival effect of α-syn PFFs after 6h of pyroxamide pre-treatment (A). Survival effect of α-syn PFFs after 3 and 6 hours of pyroxamide pre-treatment in olfactory epithelial T9243 cells (B). Survival effect of α-syn PFFs after 3 hours of pyroxamide pre-treatment in microglial BV2 cells upon α-syn PFFs-induced damage (C). Data were analyzed using one-way ANOVA. * indicates p < 0.05; ** p < 0.01; *** p < 0.001.
Article Snippet: Similar conditions were used for the Dopaminergic Neuronal Cell Line (MN9D; Merck Millipore, SCC281), and the Mouse Microglial Cell Line (BV2; Cytion, 305156), seeded at 1 × 10^4 cells/well in 96-well plates.
Techniques: In Vitro